Kuang He

Board Observer

2024 - Current

Vice President

2024

- Focused on company creations in the therapeutics space (pre-Seed, Seed financings) and occasional direct Series A-B investments - Drive strategic decision making in near-clinic and clinical-stage companies in the portfolio

Analyst/Associate

2019 - 2023

Focused on equity investments in clinical-stage pharmaceutical and medical devices companies in the CrossOver Fund. Led due diligence on: - Mainstay Medical $108m Series A in 2021 - CytoImmune $27m Series A in 2021 - Artios Pharma $153m Series C in 2021 - Amolyt Pharma $138m Series C in 2023 (acquired by AstraZeneca for $1.05b in 2024)

Clinical Research Fellow - Hematology/Oncology

2017 - 2019

- Awardee of a $85,000 NIH grant to develop non-invasive biomarkers for disease early prediction - Developed a pipeline to collect, preserved, and detect host DNA using high sensitivity and high specificity digital droplet PCR (ddPCR); used this pipeline to measure biological variations in patients during the course of their cancer treatments - Prepared IRB protocols and secured approvals - Designed and implemented clinical study protocols in collaboration with clinicians - Collected densely sampled wearable sensor data (body temperature, heart rate variability, etc) in hematopoietic stem cell transplantation and CAR-T patients for prediction of acute graft-versus-host disease (GVHD) and cytokine release syndrome (CRS), respectively - Analyzed big datasets by extracting seasonal trends, performing statistical modeling, and visualizing results using R - Developd a multiplex ddPCR assay to detect oncogenic KRAS mutations in trans-renal (urine) DNA

Business Consultant

2017 - 2017

- Conducted competitive landscape analysis by literature and global patent search, leading to identification of a strong competitor in Asia - Analyzed global market trends using business intelligence data - Conducted primary research with 7 physicians and quantified results - Delivered CEO-level presentations with recommendations for marketing campaigns at client meetings

Postdoctoral Fellow

2014 - 2016

- Designed accelerated anaerobic biodegradability tests that reduced lead discovery time from 9 months to 2 months, resulting in the discovery of 3 lead fluids - Established and managed relationships with 4 external testing and research labs ($100,000 budget) to meet project deadlines and drive product commercialization - Developed 5 technicians by training and enabling them on both professional and personal levels - Proposed and executed a new in-house research program, championing novel microbial control methods involving disruption of cell-cell communication for oil pipeline protection - Conducted risk assessments and executed hazard control to ensure laboratory safety - Re-designed the New Hire Professional Development Program to include social and team-building activities, leading to a significant increase in employee engagement and inter-departmental collaboration

Doctoral Summer Intern - Beauty & Grooming

2011 - 2011

- Optimized and validated a new inflammatory biomarker kit for assessing efficacy of anti-dandruff products - Coordinated and leveraged resources among Upstream Research, Product Development, Analytical Core, and Biostatistics Departments to meet project deadline

Science Mentor in the Chinese Flagship Program

2011 - 2011

Mentored an undergraduate student majoring in Biochemistry and Chinese with a focus on scientific reading and writing in Chinese.