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Shyam Kamadolli

Managing Director at F-Prime Capital

Boston, Massachusetts

Overview 

Shyam Kamadolli is a Managing Director at Fine Structure Ventures in Boston, Massachusetts, with expertise in venture capital, entrepreneurship, and corporate development. He has successfully invested in companies like Mantle and Mainspring Energy, contributing to their growth and success in Series C and Series D funding rounds. Kamadolli's career highlights include serving on the board of directors for innovative companies like Mainspring Energy and Mantle, showcasing his strategic leadership and investment acumen in disruptive science sectors such as ClimateTech/CleanTech and DeepTech.

Work Experience 

  • Managing Director

    2020 - Current

    At Fine Structure Ventures, an F-Prime Capital Fund (affiliated with FMR LLC, the parent company of Fidelity Investments), we back deep scientific and technical innovators raising Series-A/B/C rounds. Our VC fund is focused on revolutionary paradigms in next generation computing, energy/climate tech, biology, materials, and aerospace. Current investments include Commonwealth Fusion Systems (nuclear fusion), Mainspring Energy (on-site clean power generation), and Boston Metal (electrolytic extraction of steel).

  • Managing Director - Fine Structure Ventures

    2024

    As of July 1, 2024, Fine Structure Ventures is an F-Prime fund.

F-Prime Capital is a venture capital firm investing in healthcare and technology.

  • Member Board Of Directors

    2020

Mainspring Energy is engineering advanced technology by developing a prototype of a linear generator that converts fuel to electricity.

Raised $555,000,000.00 from US Department of Energy and BloombergNEF.

  • Member Board Of Directors

    2020

Boston Metal develops Molten Oxide Electrolysis (MOE), an electric-powered tech to decarbonize steelmaking and transform metal production.

Raised $352,746,978.00 from Marunouchi Innovation Partners, Baillie Gifford, Microsoft Climate Innovation Fund, Breakthrough Energy Ventures, BHP Ventures, Aramco Ventures, M&G Investments, Goehring & Rozencwajg Associates, Prelude Ventures and International Finance Corporation.

  • Board Observer / Investor

    2021

    Developer of a cell-free biomanufacturing technology and platform designed to create complex and high-value ingredients. The company's platform harnesses natural enzyme approaches to overcome cell limitations and provide a sustainable, low-cost, and consistent supply of natural ingredients, enabling clients to have access to sustainably produced ingredients.

Debut is an innovation company that integrates biotechnology and brand creation to build sustainable beauty businesses.

Raised $66,200,000.00 from Fine Structure Venture, Material Impact, GS Futures, Cultivian Sandbox Ventures, Cavallo Ventures, Business Opportunities for L'Oréal Development and ACVC Partners.

  • Member Board Of Directors

    2021

Mantle is metal 3D printing company that has developed technology for precision metal components such as tooling.

Raised $58,000,000.00 from Schooner Capital, Foundation Capital, 11.2 Capital, Corazon Capital, Build Collective and Fine Structure Venture.

  • Member Board of Directors

    2022

    The current generation of AI hardware (TPU, GPU, CPU) is not optimized for edge AI especially as the complexity of tasks and memory requirements increases. Femtosense has developed a 2D array of tightly coupled digital compute and memory blocks that exploit network sparsity coupled with an algorithm that trains networks to expose their underlying sparsity while maintaining performance. This coupled hardware and algorithm approach allows Femtosense to deliver the AI performance of large models in constrained edge platforms.

Femtosense is a technology company.

Raised $13,383,347.00 from MassChallenge.

  • Member Board Of Directors

    2021

Sepion is an advanced membrane company offering a platform suite of highly-tunable nanoscale membranes for multiple industrial markets.

Raised $33,500,000.00 from California Energy Commission and CALSTART.

  • Member Board of Directors

    2024

    Radian is building a next-generation spaceplane planned to be the world's first single-stage-to-orbit, truly reusable space vehicle operating in Low Earth orbit.

  • Advisor

    2019

    Early Stage Venture Capital For The African Continent: We believe the African continent is going through an economic transformation similar to the Asian boom of a decade ago and there is a significant opportunity for visionary investors to finance this transformation that will result in wealth creation and social Impact.

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