Yajie Niu

Chief Science Officer

2023 - Current

Head of Technologies

2022 - 2023

Head of External Technologies Innovation

2022 - 2022

Head Of Research

2020 - 2022

Principal

2021 - 2022

Senior Associate

2019 - 2021

Senior Director of Research Development

2017 - 2019

• Developed proprietary CRISPR tools for gene modulation • Developed and implemented high-throughput cell screening platform that enables fast validation and discovery of target leads • Implemented next generation sequencing and data analysis pipeline for efficient molecular readout and phenotyping • Supported technology and products intellectual property development

Director Of Research Development

2017 - 2017

Senior Scientist

2016 - 2017

Research Fellow

2009 - 2016

Employed integrative and novel approaches in molecular biology, functional genomics, chemical genetics, biochemistry and computational biology to: • Design and develop methodologies in calcium imaging, including construction of an ultrasensitive Ca2+ biosensor GCaMP6S and development of a leaf single-cell system for live GCaMP6S-based Ca2+ imaging • Uncover a unique temporal Ca2+ signal in nutrient signaling pathway • Develop and optimize cell-based functional genomic screen to identify different Ca2+ sensor kinases in plant immune, hormone, stress and nutrient signaling pathways • Apply protein engineering and chemical genetics to circumvent embryo lethality and functional redundancy of Ca2+ sensor kinases • Develop and optimize artificial miRNA gene-silencing, RNA-seq, MS phosphoproteomics to link Ca2+ sensor kinases to diverse intracellular effectors